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Nature's Variety pet food forms expert council to provide consumers with insight on diet's benefits

Lorne Leahan of BodySupps.com.au interviews Eric McEntyre of BioHealth Developments on the range of RedBak Protein products. www.bodysupps.com.au sells proteins, vitamins, nitric oxide, creatine. CytoSport, Optimum, RedBak, AST, Fizogen, MRI, BSN.

Think of Edward Scissorhands with a body made out of Jello. How would he not cut himself to pieces? Researchers have long asked that question about squid -- soft squishy creatures with hard, sharp beaks. As this ScienCentral News video explains, the answers could lead to a useful new class of materials.

Scientists have discovered a weakness in the AIDS virus that could lead to a new class of treatments. The virus acts like a hijacker, turning the body s own machinery against it. But the new research could deprive AIDS of those weapons.

Scientists have discovered a weakness in the AIDS virus that could lead to a new class of treatments. As this ScienCentral News video explains, the virus acts like a hijacker, turning the body's own machinery against it. But the new research could deprive AIDS of those weapons.

This time lapse video shows development of a normal neuron (left) and a mutated neuron that does not express the Ena/VASP proteins. Cultured for two days, the normal one extends an axon and many dendrites, while the mutated neuron fails to make such extensions. Full story Video / Erik Dent and Frank Gertler

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Author: Coene Added: Fri, 15 Dec 2006 18:33:32 -0800 Duration: 23 The name P450 refers to the "pigment at 450 nm", so named for the characteristic Soret peak formed by absorbance of light at wavelengths near 450 nm when the heme iron is reduced (with sodium dithionite) and complexed Animal CYPs are primarily membrane-associated proteins, located either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells. CYPs metabolise thousands of endogenous and exogenous compounds. Most CYPs can metabolize multiple substrates, and many can catalyze multiple reactions, which accounts for their central importance in metabolizing the potentially endless variety of endogenous and exogenous molecules. In the liver, these substrates include drugs and toxic compounds as well as metabolic products such as bilirubin (a breakdown product of hemoglobin). Cytochromes P450 are present in many other tissues of the body including the mucosa of the gastrointestinal tract, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. In most animals, including humans, hepatic cytochromes P450 are the most widely studied of the P450 enzymes. The Human Genome Project has identified 63 human genes (57 full genes and 5 pseudogenes) coding for the various cytochrome P450 enzymes [1]. Drug Metabolism In drug metabolism, cytochrome P450 is probably the most important element of oxidative metabolism (also known as Phase I metabolism) in animals (metabolism in this context being the chemical modification or degradation of chemicals including drugs and endogenous compounds). Many drugs may increase or decrease the activity of various CYP isozymes in a phenomenon known as enzyme induction and inhibition). This is a major source of adverse drug interactions, since changes in CYP enzyme activity may affect the metabolism and clearance of various drugs. For example, if one drug inhibits the CYP-mediated metabolism of another drug, the second drug may accumulate within the body to toxic levels, possibly causing an overdose. Hence, these drug interactions may necessitate dosage adjustments or choosing drugs which do not interact with the CYP system. In addition, naturally occurring compounds may also cause a similar effect. For example, bioactive compounds found in grapefruit juice and some other fruit juices, including bergamottin, dihydroxybergamottin, and paradisin-A, have been found to inhibit CYP3A4-mediated metabolism of certain medications, leading to increased bioavailability and thus the strong possibility of overdosing. Because of this risk, avoiding grapefruit juice and fresh grapefruits entirely while on drugs is usually advised. [edit] P450s in Plants Plant cytochrome P450s are involved in a wide range of biosynthetic reactions, leading to various fatty acid conjugates, plant hormones, defensive compounds, or medically important drugs. Terpenoids, which represent the largest class of characterized natural plant compounds, are often metabolic substrates for plant CYPs

Chemical News Central for 29September 2006. For more news on the global chemical industry, check out ICIS.com

Listen to the episode Today's guests include Dr. Robert Aronstam and Dr. Roger Brown. The cDNA Resource Center, new to UMR this fall, offers nearly 900 full-length cDNA clones of human signaling proteins. This service allows scientists to focus on basic biological questions without spending excessive amounts of time in procuring, preparing or verifying their own. Brown is leading research into how glass can be implanted in the human body to cause bone to form.